Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- Periactin (cyproheptadine)
- Zoloft (sertraline)
Interactions between your drugs
cyproheptadine sertraline
Applies to: Periactin (cyproheptadine), Zoloft (sertraline)
Cyproheptadine may reverse or reduce the effects of sertraline. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
cyproheptadine food
Applies to: Periactin (cyproheptadine)
Alcohol can increase the nervous system side effects of cyproheptadine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with cyproheptadine. Do not use more than the recommended dose of cyproheptadine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
sertraline food
Applies to: Zoloft (sertraline)
Using sertraline together with alcohol may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with sertraline. In addition, taking sertraline with grapefruit or grapefruit juice is not recommended, as it has been reported that grapefruit juice can increase the blood levels of the medication, which may lead to more side effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Do not use more than the recommended dose of sertraline, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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