Drug Interaction Report
1 drug interaction and 10 additional warnings found for the following 2 drugs:
- colesevelam
- Diavite Plus (multivitamin with minerals)
Drug interactions
Moderate drug interactions
Moderate:multivitamins with minerals colesevelam
Applies to: Diavite Plus (multivitamin with minerals), colesevelam
Colesevelam may interfere with the absorption of certain vitamins such as A, D, E and K.
Therefore, it is recommended that you take multivitamins with minerals at least 4 hours before colesevelam to minimize the risk of interaction.
Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Disease interactions
10 potential interactionsApplies to: 10 conditions, including Vitamin D Deficiency, Diabetes, Type 1, Gastroparesis, Vitamin A Deficiency, and Dysphagia.
Diabetes, Type 1
Major:colesevelam
Colesevelam has a major potential interaction with Diabetes, Type 1.
Colesevelam should not be used for glycemic control in type 1 diabetes or for treating diabetic ketoacidosis.
Diabetic Ketoacidosis
Major:colesevelam
Colesevelam has a major potential interaction with Diabetic Ketoacidosis.
Colesevelam should not be used for glycemic control in type 1 diabetes or for treating diabetic ketoacidosis.
Dysphagia
Major:colesevelam
Colesevelam has a major potential interaction with Dysphagia.
The manufacturer considers colesevelam contraindicated in patients with a history of bowel obstruction. Because of its constipating effects, colesevelam is not recommended in patients with gastroparesis, other gastrointestinal motility disorders, and in those who have had major gastrointestinal tract surgery and who may be at risk for bowel obstruction. Because of the tablet size, colesevelam tablets can cause dysphagia or esophageal obstruction and should be used with caution in patients with dysphagia or swallowing disorders.
Gastrointestinal Obstruction
Major:colesevelam
Colesevelam has a major potential interaction with Gastrointestinal Obstruction.
The manufacturer considers colesevelam contraindicated in patients with a history of bowel obstruction. Because of its constipating effects, colesevelam is not recommended in patients with gastroparesis, other gastrointestinal motility disorders, and in those who have had major gastrointestinal tract surgery and who may be at risk for bowel obstruction. Because of the tablet size, colesevelam tablets can cause dysphagia or esophageal obstruction and should be used with caution in patients with dysphagia or swallowing disorders.
Gastroparesis
Major:colesevelam
Colesevelam has a major potential interaction with Gastroparesis.
The manufacturer considers colesevelam contraindicated in patients with a history of bowel obstruction. Because of its constipating effects, colesevelam is not recommended in patients with gastroparesis, other gastrointestinal motility disorders, and in those who have had major gastrointestinal tract surgery and who may be at risk for bowel obstruction. Because of the tablet size, colesevelam tablets can cause dysphagia or esophageal obstruction and should be used with caution in patients with dysphagia or swallowing disorders.
Malabsorption Syndrome
Moderate:colesevelam
Colesevelam has a moderate potential interaction with Malabsorption Syndrome.
Bile acid sequestrants, including colesevelam may decrease the absorption of fat-soluble vitamins A, D, E, and K. Caution should be exercised when treating patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins. The manufacturer recommends to instruct patients taking colesevelam and oral vitamin supplementation to take their vitamins at least 4 hours prior to colesevelam.
Phenylketonuria
Moderate:colesevelam
Colesevelam has a moderate potential interaction with Phenylketonuria.
Questran Light and LoCholest Light (brands of cholestyramine) contain 16.8 mg and 22.4 mg of phenylalanine, respectively, per each dose. Flavored Colestid (brand of colestipol) contains 18.2 mg of phenylalanine per each 7.5-gram dose. WELCHOL (brand name of colesevelam) for Oral Suspension contains 13.5 mg phenylalanine per 1.875 gram dose and 27 mg phenylalanine per 3.75 gram dose. The phenylalanine content should be considered when these products are used in patients who must restrict their intake of phenylalanine (i.e. phenylketonurics). Regular Colestid, Questran and LoCholest do not contain phenylalanine.
Vitamin A Deficiency
Moderate:colesevelam
Colesevelam has a moderate potential interaction with Vitamin A Deficiency.
Bile acid sequestrants, including colesevelam may decrease the absorption of fat-soluble vitamins A, D, E, and K. Caution should be exercised when treating patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins. The manufacturer recommends to instruct patients taking colesevelam and oral vitamin supplementation to take their vitamins at least 4 hours prior to colesevelam.
Vitamin D Deficiency
Moderate:colesevelam
Colesevelam has a moderate potential interaction with Vitamin D Deficiency.
Bile acid sequestrants, including colesevelam may decrease the absorption of fat-soluble vitamins A, D, E, and K. Caution should be exercised when treating patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins. The manufacturer recommends to instruct patients taking colesevelam and oral vitamin supplementation to take their vitamins at least 4 hours prior to colesevelam.
Vitamin K Deficiency
Moderate:colesevelam
Colesevelam has a moderate potential interaction with Vitamin K Deficiency.
Bile acid sequestrants, including colesevelam may decrease the absorption of fat-soluble vitamins A, D, E, and K. Caution should be exercised when treating patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins. The manufacturer recommends to instruct patients taking colesevelam and oral vitamin supplementation to take their vitamins at least 4 hours prior to colesevelam.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.