Drug Interaction Report

It is possible that lonafarnib may interfere with the effects of clopidogrel in some patients. This may make the medication less effective in preventing heart attacks and strokes. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Lonafarnib should be taken with the morning and evening meals and an adequate amount of water. Do not consume grapefruit, grapefruit juice, or Seville oranges (also known as bitter or sour oranges).During treatment with lonafarnib. Juice from grapefruits and Seville oranges can increase the blood levels of lonafarnib. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, loss of appetite, electrolyte (e.G., calcium, magnesium, potassium, phosphate, sodium) abnormalities, liver problems, low red and white blood cell counts, infection, and high blood pressure. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.