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Generic Name: lonafarnib
Dosage Form: capsules

Medically reviewed by Judith Stewart, BPharm. Last updated on Nov 24, 2020.

What is Zokinvy?

Zokinvy is a prescription medicine used to:

  • lower the risk of death in adults and children 12 months of age or older with Hutchinson-Gilford Progeria Syndrome (HGPS), who have a certain body surface area.
  • treat adults and children 12 months of age or older with certain types of Progeroid Laminopathies, who have a certain body surface area.

Zokinvy is not for use in people with non-HGPS Progeroid Syndromes or with Progeroid Laminopathies that are processing-proficient.

It is not known if this medicine is safe and effective in children under 12 months of age.

Who should not take Zokinvy?

You should not take Zokinvy if you are taking:

  • a strong or moderate CYP3A inhibitor or inducer
  • midazolam
  • lovastatin or simvastatin or atorvastatin

Ask your healthcare provider if you are not sure if your medicine may be one that is listed above.

Before taking Zokinvy

Before taking Zokinvy, tell your healthcare provider about all of your medical conditions, including if you:

  • have kidney problems.
  • have eye problems.
  • are pregnant or plan to become pregnant. Zokinvy can harm your unborn baby. Females who are able to become pregnant should use effective birth control (contraception) during treatment.
  • are breastfeeding or plan to breastfeed. It is not known if Zokinvy can pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking Zokinvy with certain other medicines may affect how the other medicines work and other medicines may affect how Zokinvy works, and may increase your risk of side effects.

Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist when starting a new medicine.

How should I take Zokinvy?

  • Take Zokinvy exactly as your healthcare provider tells you to.
  • Do not stop taking this medicine without talking to your healthcare provider. Your healthcare provider my change your dose if needed.
  • Your healthcare provider will provide you with the dose you should be taking. The dose is based on body size (height and weight).
  • Take Zokinvy 2 times a day, with morning and evening meals.
  • Swallow the capsules whole with an adequate amount of water. Do not chew the capsules.
  • If you or your child cannot swallow the capsule whole, see the detailed Instructions for Use that comes with Zokinvy for information about how to prepare and give or take a dose by mixing the contents of a Zokinvy capsule with either Ora Blend SF, Ora-Plus, orange juice, or applesauce.
  • Each dose of Zokinvy mixture must be prepared fresh and taken within about 10 minutes of mixing.
  • Do not take Zokinvy with any juice that contains grapefruit or Seville oranges. Seville oranges may also be called bitter or sour oranges.
  • If you miss a dose, take it as soon as possible up to 8 hours before your next scheduled dose with food.
  • If it is less than 8 hours before your next dose, skip the missed dose and take Zokinvy at your next regularly scheduled dose.

Zokinvy side effects

Zokinvy may cause serious side effects, including:

Severe kidney problems, Zokinvy may cause severe kidney problems. Your healthcare provider will monitor your kidney function regularly during treatment with Zokinvy.
Eye problems. Zokinvy may cause problems with night vision. Call your healthcare provider right away if you develop any new changes in your vision.

The most common side effects include:

  • vomiting
  • diarrhea
  • infection
  • nausea
  • decreased appetite
  • tiredness
  • upper respiratory tract infection
  • stomach-area (abdominal) pain
  • muscle and joint (musculoskeletal) pain
  • electrolyte abnormalities
  • decreased weight
  • headache
  • myelosuppression
  • increased liver enzyme blood test results
  • decreased blood bicarbonate
  • cough
  • hypertension

Call your healthcare provider if you continue to have nausea, vomiting or diarrhea that leads to loss of appetite and weight loss during your treatment.

Zokinvy may cause an increase in your blood pressure (hypertension). Your healthcare provider will check your blood pressure during treatment.

Call your healthcare right away if you develop any symptoms of high blood pressure including: headaches, shortness of breath, nosebleeds, flushing, tiredness, dizziness, vision problems, irregular heartbeat, or chest pain.

Zokinvy may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if you have concerns about fertility.

These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA 1088. You may also report side effects to Eiger BioPharmaceuticals at 1-833-267-0545.

How should I store Zokinvy?

  • Store at room temperature between 68°F to 77°F (20°C to 25°C)

Keep all medicines out of reach of children and pets.

General information about the safe and effective use of Zokinvy

Medicines are sometimes prescribed for purposes other than those listed in the Patient Information. Do not use this medicine for a condition for which it was not prescribed. Do not give Zokitinvy to other people, even if they have the same symptoms that you have. It may harm them. You can ask your healthcare provider or pharmacist for information that is written for health professionals.

What are the ingredients in Zokinvy?

Active ingredient: lonafarnib
Inactive ingredients: croscarmellose sodium, magnesium stearate, poloxamer 188, povidone, and silicon dioxide.
The capsule shell (Zokinvy 50 mg hard capsule) contains: gelatin, titanium dioxide and yellow iron oxide
The capsule shell (Zokinvy 75 mg hard capsule) contains: gelatin, titanium dioxide, yellow iron oxide and red iron oxide.
The printing ink contains: ammonia solution, black iron oxide, butyl alcohol, dehydrated alcohol, isopropyl alcohol, potassium hydroxide, propylene glycol, purified water, and shellac.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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