Drug Interaction Report

Talk to your doctor before using colchicine together with clofibrate. Combining these medications may increase the risk of a rare but serious and potentially fatal condition that affects your muscles and kidneys. The risk is greatest if you are elderly or have preexisting kidney disease. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. Let your doctor know if you experience abdominal pain, nausea, vomiting, diarrhea, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Drinking large amounts of grapefruit juice can increase your blood levels of colchicine to dangerous levels. You should avoid the consumption of grapefruit or grapefruit juice during treatment with colchicine. Let your doctor know if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet, as these may be early symptoms of colchicine toxicity.