Drug Interaction Report

Cholestyramine may interfere with the absorption of pravastatin when they are taken at the same time or within a short time of each other. This may reduce the blood levels and effects of pravastatin. To prevent or minimize the risk of interaction, pravastatin should be taken at least 1 hour before or 4 hours after cholestyramine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Pravastatin may cause liver problems and using it with substantial quantities of ethanol (alcohol) may increase that risk. You should limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Cholestyramine may interfere with the absorption of certain vitamins such as A, D, E and K. Therefore, it is recommended that you take multivitamin with minerals at least 1 hour before or 4 to 6 hours after cholestyramine to minimize the risk of interaction. Talk to your doctor or pharmacist if you have questions on how to take these or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.