Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Tryvio (aprocitentan)
- tucatinib
Interactions between your drugs
tucatinib aprocitentan
Applies to: tucatinib, Tryvio (aprocitentan)
MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations of tucatinib, which is primarily metabolized by the isoenzyme. When gemfibrozil (600 mg twice daily), a potent CYP450 2C8 inhibitor, was administered with a single tucatinib dose of 300 mg, tucatinib peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.6-fold and 3-fold, respectively.
MANAGEMENT: Increased monitoring is advised if tucatinib is coadministered with CYP450 2C8 inhibitors. Dosage adjustments may be required based on clinical response and tolerance.
References (1)
- (2020) "Product Information. Tukysa (tucatinib)." Seattle Genetics Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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