Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- aprocitentan
- bupivacaine / meloxicam
Interactions between your drugs
meloxicam aprocitentan
Applies to: bupivacaine / meloxicam, aprocitentan
MONITOR: Coadministration with CYP450 2C9 inhibitors may increase the plasma concentration of meloxicam, which has been shown to be primarily metabolized by this isoenzyme. In a study of healthy volunteers, voriconazole, a weak CYP450 2C9 inhibitor increased the systemic exposure of meloxicam by 47% and prolonged the average meloxicam half-life by 51%.
MANAGEMENT: The potential for an interaction should be considered during concomitant use. If coadministration is required, monitor patients for NSAID-related side effects and toxicity including gastrointestinal bleeding or perforation. Dose adjustment of meloxicam may be warranted.
References (6)
- (2025) "Product Information. Symbravo (meloxicam-rizatriptan)." Axsome Therapeutics, Inc.
- (2025) "Product Information. Meloxicam (meloxicam)." Lupin Pharmaceuticals Inc
- (2024) "Product Information. Meloxicam (meloxicam)." Flamingo Pharma (UK) Ltd
- (2017) "Product Information. Meloxicam (meloxicam)." Teva Canada Limited
- (2024) "Product Information. Meloxicam (WGR) (meloxicam)." GM Pharma International Pty Ltd
- Hynninen VV, Olkkola KT, Bertilsson L, Kurkinen KJ, Korhonen T, Neuvonen PJ, Laine K (2009) "Voriconazole increases while itraconazole decreases plasma meloxicam concentrations" Antimicrob Agents Chemother, 53, p. 587-92
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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