Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- aprocitentan
- L-Arginine (arginine)
Interactions between your drugs
arginine aprocitentan
Applies to: L-Arginine (arginine), aprocitentan
MONITOR: Coadministration of L-arginine or L-citrulline may potentiate the hypotensive effects of nitrates and vasodilators. Both L-arginine and L-citrulline are amino acid precursors to nitric oxide, which causes vasodilation and increased blood flow.
MANAGEMENT: Due to potentially additive effects in the vasculature, caution is advised during concomitant use of L-arginine or L-citrulline with nitrates and vasodilators. Blood pressure and heart rate should be closely monitored.
References (1)
- Stokes GS, Barin ES, Gilfillan KL, Kaesemeyer WH (2003) "Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave." Am J Hypertens, 16, p. 719-24
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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