Drug Interaction Report

Ritonavir may decrease the blood levels and effects of aprocitentan. Monitor your blood pressure closely and speak with your healthcare provider if you have any questions or concerns. In addition, aprocitentan and ritonavir may share similar side effects, such as liver problems, so there is also a possibility that the risk of shared side effects might be increased. Seek immediate medical attention if you notice any nausea, vomiting, pain in the upper right part of your stomach, tiredness, lack of appetite, yellowing of your skin or eyes, dark urine, fever, or itching as these could be signs of a serious liver problem that may occur with aprocitentan treatment. Your doctor may already be aware of these possibilities, but has determined that this is the best course of treatment for you and is monitoring you for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

Food may affect the absorption of lopinavir-ritonavir (brand name Kaletra) depending on whether you are taking the oral solution or the tablet. The oral solution should be taken with food to enhance absorption and help it work better. The tablet formulation can be take with or without food. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.