Drug Interaction Report

Using bimekizumab together with temsirolimus may increase the risk of serious infections. In addition, bimekizumab may decrease the blood levels and effects of temsirolimus. You may need a dose adjustment if you have been receiving temsirolimus and are starting treatment with bimekizumab. Likewise, if you have been receiving both medications, the dose of temsirolimus may need to be adjusted if bimekizumab is discontinued. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

If you are receiving therapy with temsirolimus you should avoid grapefruits and grapefruit juice. Grapefruit can raise the levels of temsirolimus in your body and lead to dangerous side effects. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.