Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Omega MonoPure Curcumin EC (omega-3 polyunsaturated fatty acids / turmeric)
- sulfasalazine
Interactions between your drugs
sulfaSALAzine turmeric
Applies to: sulfasalazine, Omega MonoPure Curcumin EC (omega-3 polyunsaturated fatty acids / turmeric)
MONITOR: Coadministration with turmeric may increase the plasma concentrations of sulfasalazine. The proposed mechanism involves enhanced bioavailability of sulfasalazine due to inhibition of breast cancer resistance protein (BCRP)-mediated intestinal efflux by curcumin, an active constituent of turmeric. When a single 2 gm dose of sulfasalazine was administered orally to 8 healthy male volunteers 30 minutes following a 2 gm dose of curcumin, mean sulfasalazine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 3.7- and 3.2-fold, respectively, compared to administration of the sulfasalazine dose alone.
MANAGEMENT: Caution is advised when sulfasalazine is used with turmeric-containing products. Patients should be monitored for serious adverse effects of sulfasalazine such as blood dyscrasias, myelosuppression, infections, hepatotoxicity, and renal impairment.
References (1)
- Kusuhara H, Furuie H, Inano A, et al. (2012) "Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP." Br J Pharmacol, 166, p. 1793-803
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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