Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Cystex Urinary Pain Relief (methenamine / sodium salicylate)
- levamlodipine
Interactions between your drugs
sodium salicylate levamlodipine
Applies to: Cystex Urinary Pain Relief (methenamine / sodium salicylate), levamlodipine
MONITOR: Limited data indicate that some cyclooxygenase inhibitors may attenuate the antihypertensive effects of some calcium channel blockers. The mechanism appears to be related to an alteration of vascular tone, which is dependent on prostacyclins and other vasodilatory prostanoids. When a nonsteroidal anti-inflammatory drug (NSAID) is added to the regimen of a patient who is already taking a calcium channel blocker, increased blood pressure may result. Also, the clinician should be aware that the risk of hypotension is increased when NSAIDs are withdrawn from the regimen.
MANAGEMENT: Monitoring for altered blood pressure control is recommended.
References (9)
- Ring ME, Corrigan JJ, Fenster PE (1986) "Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin." Thromb Res, 44, p. 391-400
- Altman R, Scazziota A, Dujovne C (1988) "Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation." Clin Pharmacol Ther, 44, p. 320-5
- Cremer KF, Pieper JA, Joyal M, Mehta J (1984) "Effects of diltiazem, dipyridamole, and their combination on hemostasis." Clin Pharmacol Ther, 36, p. 641-4
- Minuz P, Pancera P, Ribul M, et al. (1995) "Amlodipine and haemodynamic effects of cyclo-oxygenase inhibition." Br J Clin Pharmacol, 39, p. 45-50
- Houston MC, Weir M, Gray J, et al. (1995) "The effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamil." Arch Intern Med, 155, p. 1049-54
- Deleeuw PW (1996) "Nonsteroidal anti-inflammatory drugs and hypertension: the risks in perspective." Drugs, 51, p. 179-87
- "Product Information. DurAct (bromfenac)." Wyeth-Ayerst Laboratories
- (2001) "Product Information. Arthrotec (diclofenac-misoprostol)." Searle
- Zanchetti A, Hansson L, Leonetti G, et al. (2002) "Low-dose aspirin does not interfere with the blood pressure-lowering effects of antihypertensive therapy." J Hypertens, 20, p. 1015-1022
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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