Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- levamlodipine
- Tracrium (atracurium)
Interactions between your drugs
atracurium levamlodipine
Applies to: Tracrium (atracurium), levamlodipine
MONITOR: Some calcium channel blockers may enhance the neuromuscular blocking properties of nondepolarizing muscle relaxants. The mechanism is not known, but may involve blockage of calcium channels on skeletal muscle. Data are available for verapamil, diltiazem, nicardipine, atracurium, vecuronium, and pancuronium.
MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade. Reduced doses of muscle relaxants may be necessary. Profound neuromuscular blockade may be reversed by neostigmine or edrophonium.
References (4)
- Carlos R, Erill S (1986) "Therapeutic Rounds." Clin Ther, 9, p. 22-3
- Wali FA (1987) "Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction." Acta Anaesthesiol Scand, 31, p. 15-20
- Sekerci S, Tulunay M (1996) "Interactions of calcium channel blockers with non-depolarising muscle relaxants in vitro." Anaesthesia, 51, p. 140-4
- Saitoh Y, Makita K, Tanaka H (1997) "Diltiazem and vecuronium: neuromuscular and cardiovascular effects." Can J Anaesth, 44, p. 99
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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