Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Erleada (apalutamide)
- vorapaxar
Interactions between your drugs
vorapaxar apalutamide
Applies to: vorapaxar, Erleada (apalutamide)
GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with rifampin 600 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 35% and 50%, respectively.
MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inducers should generally be avoided due to the potential for reduced efficacy.
References (1)
- (2014) "Product Information. Zontivity (vorapaxar)." Merck & Co., Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Premarin
Premarin is used to treat symptoms of menopause such as hot flashes, and vaginal dryness. Learn ...
Estrace
Estrace (estradiol) is used to treat symptoms of menopause such as hot flashes and vaginal dryness ...
Botox
Botox is used for cosmetic purposes and to treat overactive bladder symptoms, urinary incontinence ...
Eligard
Eligard (leuprolide) reduces levels of testosterone and is used to treat prostate cancer. Includes ...
Xtandi
Xtandi (enzalutamide) is an anti-androgen used to treat prostate prostate cancer. Includes Xtandi ...
Orgovyx
Orgovyx (relugolix) is used for the treatment of advanced prostate cancer. Includes Orgovyx side ...
Zytiga
Zytiga (abiraterone) is used together with prednisone to treat prostate cancer that has spread to ...
Lupron Depot
Lupron Depot (leuprolide acetate) and Lupron Depot-Ped are prescription hormonal injections used to ...
Casodex
Casodex (bicalutamide) is an anti-androgen and is used together with LHRH to treat prostate cancer ...
Estradiol Patch
Estradiol Patch is used for atrophic urethritis, atrophic vaginitis, breast cancer, palliative ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.