Drug Interaction Report

Idelalisib may cause serious and life-threatening diarrhea, and using it with other medications that also commonly cause diarrhea such as inavolisib may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. Call your doctor immediately if the number of bowel movements per day increases by six or more, or if you experience new or worsening abdominal pain, chills, fever, nausea, or vomiting. You may need a dose adjustment or an interruption in idelalisib therapy if you develop severe diarrhea. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

The recommended maximum number of medicines in the 'PI3K inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'PI3K inhibitors' category:

• idelalisib
• inavolisib

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.