Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fospropofol
- sevoflurane
Interactions between your drugs
sevoflurane fospropofol
Applies to: sevoflurane, fospropofol
MONITOR: Additive central nervous system and cardiorespiratory depressant effects may occur when fospropofol or propofol is administered with other depressants such as sedative-hypnotic agents and narcotic analgesics.
MANAGEMENT: Patients should be monitored closely for excessive sedation and cardiorespiratory depression, and the medication dosage(s) adjusted accordingly. Supportive therapy should be provided if needed.
References (10)
- McClune S, McKay AC, Wright PM, et al. (1992) "Synergistic interaction between midazolam and propofol." Br J Anaesth, 69, p. 240-5
- Gill SS, Wright EM, Reilly CS (1990) "Pharmacokinetic interaction of propofol and fentanyl: single bolus injection study." Br J Anaesth, 65, p. 760-5
- (2001) "Product Information. Diprivan (propofol)." Astra-Zeneca Pharmaceuticals
- Pavlin DJ, Coda B, Shen DD, et al. (1996) "Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers." Anesthesiology, 84, p. 23-37
- Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A (1999) "Propofol decreases the clearance of midazolam by inhibiting CYP3A4: An in vivo and in vitro study." Clin Pharmacol Ther, 66, p. 110-7
- (2008) "Product Information. Lusedra (fospropofol)." Eisai Inc
- (2024) "Product Information. propOFol Lipuro (B Braun) (propOFol)." B Braun Australia Pty Ltd, 3
- (2023) "Product Information. Diprivan (propofol)." Aspen Pharmacare Canada Inc
- (2024) "Product Information. Propofol (Lipuro) (propofol)." B.Braun Medical Ltd
- (2024) "Product Information. Propofol (propofol)." Hospira Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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