Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Azasan (azathioprine)
- cyclophosphamide
Interactions between your drugs
azaTHIOprine cycloPHOSphamide
Applies to: Azasan (azathioprine), cyclophosphamide
MONITOR: Concomitant administration of azathioprine and cyclophosphamide may cause hepatotoxicity, in some cases associated with hepatocellular necrosis. The mechanism is unknown. In addition, the risk of bone marrow suppression may be increased when azathioprine and cyclophosphamide are coadministered.
MANAGEMENT: If concomitant therapy is needed patients should be monitored for signs and symptoms of hepatotoxicity and myelotoxicity. Patients should be advised to promptly notify their physician if they experience fever, chills, sore throat, mouth sores, unusual fatigue, bleeding, bruising, abdominal pain, darkened urine, or pale stools.
References (1)
- Shaunak S, Munro JM, Weinbren K, Walport MJ, Cox TM (1988) "Cyclophosphamide-induced liver necrosis: a possible interaction with azathioprine." Q J Med, 67, p. 309-17
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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