Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Bystolic (nebivolol)
- zileuton
Interactions between your drugs
zileuton nebivolol
Applies to: zileuton, Bystolic (nebivolol)
MONITOR: Zileuton is believed to inhibit the hepatic metabolism of propranolol. Propranolol serum concentrations may increase by as much as 100% with a resultant increase in beta blockade.
MANAGEMENT: It is unknown if this interaction will occur with other beta-blockers; however, if zileuton and a beta-blocker must be given concomitantly, the patient should be monitored for orthostatic hypotension, cardiac arrhythmias, bradycardia, and heart failure, and beta-blocker dosage should be decreased if necessary.
References (1)
- "Product Information. Zyflo (zileuton)." Abbott Pharmaceutical
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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