Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- estradiol topical
- letrozole
Interactions between your drugs
letrozole estradiol topical
Applies to: letrozole, estradiol topical
GENERALLY AVOID: Theoretically, estrogen-containing drugs may negate the pharmacologic effects of aromatase inhibitors in the treatment of hormone-dependent breast cancer. Aromatase inhibitors induce a state of estrogen deprivation in postmenopausal women by inhibiting the conversion of androgens to estrogens in adrenal and ovarian tissues, thus estrogen administration would be expected to reverse their therapeutic effects.
MANAGEMENT: Use of estrogen-containing products should be avoided during aromatase inhibitor therapy.
References (3)
- (2001) "Product Information. Femara (letrozole)." Novartis Pharmaceuticals
- (2001) "Product Information. Arimidex (anastrozole)." Astra-Zeneca Pharmaceuticals
- (2001) "Product Information. Aromasin (exemestane)." Pharmacia and Upjohn
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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