Drug Interaction Report

Inotersen may cause kidney problems including glomerulonephritis, which is an inflammatory condition of the kidney. Glomerulonephritis may result in kidney failure, and combining it with other medications that can also affect the kidney such as mesalamine may increase that risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. You should seek immediate medical attention if you develop signs and symptoms that may suggest glomerulonephritis such as puffiness or swelling in the face, hands, or feet; new onset or worsening shortness of breath or coughing; blood in the urine or brown urine; foamy urine (protein in the urine); and decreased urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.