Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Neutrexin (trimetrexate)
- sapropterin
Interactions between your drugs
trimetrexate sapropterin
Applies to: Neutrexin (trimetrexate), sapropterin
MONITOR: Drugs that affect folate metabolism may reduce the efficacy of sapropterin, which is a synthetic form of tetrahydrobiopterin (BH4). Folate antagonists can decrease tetrahydrobiopterin (BH4) levels by inhibiting the enzyme dihydropteridine reductase.
MANAGEMENT: Caution is advised if sapropterin is used in combination with folate antagonists. The potential for diminished pharmacologic effects of sapropterin should be considered.
References (1)
- (2007) "Product Information. Kuvan (sapropterin)." BioMarin Pharmaceutical Inc
Drug and food interactions
sapropterin food
Applies to: sapropterin
ADJUST DOSING INTERVAL: Food increases the gastrointestinal absorption of sapropterin.
MANAGEMENT: Sapropterin should be administered with food, preferably at the same time each day. Sapropterin tablets should be dissolved in 4 to 8 ounces (120 to 240 mL) of water or apple juice and taken within 15 minutes of dissolution.
References (4)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- (2007) "Product Information. Kuvan (sapropterin)." BioMarin Pharmaceutical Inc
- Cerner Multum, Inc. "Australian Product Information."
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Bactrim
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections, urinary ...
Cleocin
Cleocin (clindamycin) is used to treat serious bacterial infections. Includes Cleocin side effects ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
SMZ-TMP DS
SMZ-TMP DS (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections ...
Co-trimoxazole
Co-trimoxazole is used for bacterial infection, bacterial skin infection, bronchitis ...
Atovaquone
Atovaquone is used for babesiosis, malaria, pneumocystis pneumonia, pneumocystis pneumonia ...
Dapsone
Dapsone is used for bullous pemphigoid, dermatitis herpetiformis, leprosy, leprosy, lepromatous ...
Leucovorin
Leucovorin is used for anemia, megaloblastic, colorectal cancer, folic acid antagonist overdose ...
Trimethoprim
Trimethoprim is used for bladder infection, middle ear infections, pneumocystis pneumonia ...
Sulfamethoxazole/trimethoprim
Sulfamethoxazole/trimethoprim is used for acne, bacterial infection, bacterial skin infection ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.