Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- sulfasalazine
- Tagrisso (osimertinib)
Interactions between your drugs
sulfaSALAzine osimertinib
Applies to: sulfasalazine, Tagrisso (osimertinib)
MONITOR: Coadministration with osimertinib may increase the exposure of breast cancer resistance protein (BCRP) transporter substrates. In vitro studies have shown that osimertinib is a competitive inhibitor of BCRP. In a clinical pharmacokinetic study, concomitant use of osimertinib with the BCRP substrate rosuvastatin increased the systemic exposure (AUC) and peak plasma concentration (Cmax) of rosuvastatin by 35% and 72%, respectively.
MANAGEMENT: Caution is recommended if osimertinib is used in combination with drugs that are substrates of the BCRP transporter, particularly those with a narrow therapeutic index. Monitoring for signs and symptoms of increased exposure to the BCRP substrate should be considered whenever osimertinib is added to or withdrawn from therapy.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2015) "Product Information. Tagrisso (osimertinib)." Astra-Zeneca Pharmaceuticals
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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