Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Citrocarbonate (sodium bicarbonate / sodium citrate)
- mycophenolate mofetil
Interactions between your drugs
sodium bicarbonate mycophenolate mofetil
Applies to: Citrocarbonate (sodium bicarbonate / sodium citrate), mycophenolate mofetil
ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of mycophenolic acid. The exact mechanism of interaction is unknown but may involve chelation with polyvalent ions in antacids or enhanced drug solubility induced by an increase in gastric pH, or both. The interaction has been reported with magnesium/aluminum-containing antacids.
MANAGEMENT: Patients treated with oral mycophenolic acid who require an antacid or antacid-containing preparation (e.g., didanosine buffered tablets or pediatric oral solution) should separate the administration times of the medications by at least two hours.
References (4)
- (2001) "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories
- Bullingham R, Shah J, Goldblum R, Schiff M (1996) "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol, 41, p. 513-6
- Lipsky JJ (1996) "Mycophenolate mofetil." Lancet, 348, p. 1357-9
- (2004) "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals
sodium citrate mycophenolate mofetil
Applies to: Citrocarbonate (sodium bicarbonate / sodium citrate), mycophenolate mofetil
ADJUST DOSING INTERVAL: Coadministration with antacids may decrease the oral bioavailability of mycophenolic acid. The exact mechanism of interaction is unknown but may involve chelation with polyvalent ions in antacids or enhanced drug solubility induced by an increase in gastric pH, or both. The interaction has been reported with magnesium/aluminum-containing antacids.
MANAGEMENT: Patients treated with oral mycophenolic acid who require an antacid or antacid-containing preparation (e.g., didanosine buffered tablets or pediatric oral solution) should separate the administration times of the medications by at least two hours.
References (4)
- (2001) "Product Information. CellCept (mycophenolate mofetil)." Roche Laboratories
- Bullingham R, Shah J, Goldblum R, Schiff M (1996) "Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients." Br J Clin Pharmacol, 41, p. 513-6
- Lipsky JJ (1996) "Mycophenolate mofetil." Lancet, 348, p. 1357-9
- (2004) "Product Information. Myfortic (mycophenolic acid)." Novartis Pharmaceuticals
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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