Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Posicor (mibefradil)
- riluzole
Interactions between your drugs
riluzole mibefradil
Applies to: riluzole, Posicor (mibefradil)
In vitro studies indicate that mibefradil inhibits the metabolism of drugs that are substrates of the CYP450 1A2 microsomal pathway. This may result in elevated plasma concentrations of these drugs. The manufacturer reports no pharmacokinetic interaction was observed when theophylline, a known substrate of CYP450 1A2, was studied with mibefradil. However, until specific information is available, observation for altered clinical and laboratory effects is recommended if these agents must be used with mibefradil.
References (2)
- (2001) "Product Information. Posicor (mibefradil)." Roche Laboratories
- Thijssen HH, Flin ois JP, Beaune PH (2000) "Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes." Drug Metab Dispos, 28, p. 1284-90
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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