Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- alosetron
- Procan SR (procainamide)
Interactions between your drugs
procainamide alosetron
Applies to: Procan SR (procainamide), alosetron
Theoretically, coadministration with alosetron may increase the plasma concentrations of drugs that undergo metabolism by N-acetyltransferase such as hydralazine, isoniazid, and procainamide. In an in vivo metabolic probe study, alosetron produced 30% inhibition of N-acetyltransferase. However, concomitant administration of alosetron with substrates of N-acetyltransferase has not been evaluated, and the clinical significance of such an interaction is unknown.
References (1)
- (2001) "Product Information. Lotronex (alosetron)." Glaxo Wellcome
Drug and food interactions
procainamide food
Applies to: Procan SR (procainamide)
Ethanol may increase the acetylation of procainamide. Subtherapeutic plasma levels of procainamide may result in some patients. Because the acetylated metabolite of procainamide also possesses antiarrhythmic properties, the clinical effects are unclear.
References (1)
- Olsen H, Morland J (1982) "Ethanol-induced increase in procainamide acetylation in man." Br J Clin Pharmacol, 13, p. 203-8
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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