Drug Interaction Report

Using futibatinib together with hydroxychloroquine may increase the risk of serious and potentially irreversible eye problems. You will need to have regular eye exams during your treatment with hydroxychloroquine. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. If you notice any changes in your vision, like blurred vision, floaters, or flashes of light, you should seek immediate medical attention during treatment with these medications, whether together or individually. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit juice can increase the blood levels of futibatinib. This may increase side effects including dry or inflamed eyes, inflamed cornea, increased tears, disorder of the retina, high phosphate levels in your blood, redness, swelling, peeling or tenderness, mainly on the hands or feet, nails separating from the bed or poor formation of the nail, urinary tract infection, constipation, diarrhea, dry mouth, abdominal pain, fatigue, muscle and joint pain, decreased levels of blood cells (white blood cells, red blood cells, and platelets), and changes in liver function blood tests. You should avoid the consumption of grapefruit and grapefruit juice during treatment with futibatinib. Be sure to take the medication at approximately the same time every day to maintain consistent blood levels and effects. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You may want to limit your consumption of grapefruit or grapefruit juice during treatment with hydroxychloroquine. Grapefruit juice can significantly increase the blood levels and effects of hydroxychloroquine, which may result in an irregular heart rate or other conduction disturbances. Hydroxychloroquine should also be taken with food or milk to reduce the incidence of stomach upset. Talk to your doctor if you have any questions or concerns. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with hydroxychloroquine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.