Drug Interaction Report

If you are currently being treated with aliskiren, let your doctor know before you receive amifostine. Combining these medications may have additive effects in lowering your blood pressure. Depending on your condition, your doctor may want you to discontinue aliskiren for 24 hours before you receive treatment with amifostine, and your blood pressure will need to be monitored closely during and after the treatment. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. Contact your doctor if you develop these symptoms and they do not go away after a few hours, or they become troublesome. You should avoid rising abruptly from a sitting or lying position until you know how these medications affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can affect the absorption of aliskiren from the intestine. Therefore, you should take aliskiren at the same time each day exactly as prescribed by your doctor. You may take aliskiren with or without food, but take it the same way every time. This will help keep blood levels and effects of the medication steady. You should avoid drinking orange, apple, or grapefruit juice as much as possible during treatment with aliskiren. Studies have shown that drinking these juices regularly or within a short period before or after a dose of aliskiren can interfere with the absorption of the medication.