Drug Interaction Report

Using alemtuzumab together with ifosfamide may increase the risk of serious infections. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you, has taken appropriate precautions, and is monitoring you closely for any potential complications. It has been recommended that you either do not ingest or properly heat foods that may be a source of listeria like deli meat, unpasteurized milk and cheese products, soft cheeses, or undercooked meat, seafood or poultry. Contact your doctor immediately if you develop signs and symptoms of a serious side effect or infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your phlegm, weight loss, red or inflamed skin, body sores, pain or burning during urination, weakness on one side of your body, and/or problems with thinking, eyesight, strength, balance, or use of your arms or legs. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice while you are receiving treatment with ifosfamide, as this may decrease the anticancer effects of ifosfamide and may increase its adverse effects on your nervous system and your kidneys. Do not use alcohol while you are receiving treatment with ifosfamide. This may increase nervous system side effects such as somnolence, dizziness, confusion, difficulty concentrating, and impairment of thinking and judgment; and may also increase nausea and vomiting. Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed. Also, avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.