Drug Interaction Report

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with strong inducers of CYP450 3A4 or the pregnane X receptor (PXR) (e.g. carbamazepine, phenytoin, rifampin, St. John's wort) may decrease the plasma concentrations of vamorolone leading to a lack of efficacy. Vamorolone is partially metabolized in vitro by CYP3A4. The clinical significance of this interaction is unknown.

MANAGEMENT: Some authorities recommend considering the use of alternative treatments that are not strong inducers of CYP3A4 during concomitant use with vamorolone due to reduced vamorolone efficacy. No dose adjustments are recommended. The possibility of decreased corticosteroid effects should be considered. Patients should be monitored for signs and symptoms of steroid withdrawal and secondary renal insufficiency, including anorexia, hypoglycemia, nausea, vomiting, weight loss, muscle wasting, fatigue, weakness, dizziness, postural hypotension, depression, and adrenal crisis manifested as inability to respond to stress (e.g., illness, infection, surgery, trauma).

Grapefruit juice may increase the blood levels and effects of vamorolone. This may increase the risk and/or severity of side effects such as swelling, weight gain, electrolyte abnormalities, high blood pressure, high blood glucose, muscle weakness, depression, mood swings, acne, thinning skin, stretch marks, easy bruising, cataracts, glaucoma, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.