Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Sesquient (fosphenytoin)
- succinylcholine
Interactions between your drugs
succinylcholine fosphenytoin
Applies to: succinylcholine, Sesquient (fosphenytoin)
MONITOR: Chronic administration of anticonvulsants, including phenytoin and/or carbamazepine may prolong the effects of succinylcholine. The mechanism may be related to anticonvulsant-induced up-regulation of acetylcholine receptors.
MANAGEMENT: Close observation for reduced or prolonged succinylcholine effect is recommended if this drug must be used in a patient receiving chronic anticonvulsant therapy.
References (1)
- Melton AT, Antognini JF, Gronert GA (1993) "Prolonged duration of succinylcholine in patients receiving anticonvulsants: evidence for mild up-regulation of acetylcholine receptors?" Can J Anaesth, 40, p. 939-42
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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