Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- eptifibatide
- tirofiban
Interactions between your drugs
tirofiban eptifibatide
Applies to: tirofiban, eptifibatide
CONTRAINDICATED: Concomitant use of multiple glycoprotein (GP) IIb/IIIa inhibitors may increase the risk of major bleeding events due to additive anticoagulation.
MANAGEMENT: Some authorities consider concomitant use of multiple GP IIb/IIIa inhibitors to be contraindicated. If concomitant use is considered, close clinical and laboratory observation for bleeding complications, especially at arterial puncture sites, is recommended. Therapy should be immediately discontinued if serious or uncontrollable bleeding occurs.
References (5)
- (2001) "Product Information. ReoPro (abciximab)." Lilly, Eli and Company
- (2001) "Product Information. Aggrastat (tirofiban)." Merck & Co., Inc
- (2001) "Product Information. Integrilin (eptifibatide)." Schering Corporation
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Glycoprotein IIb/IIIa inhibitors
Therapeutic duplication
The recommended maximum number of medicines in the 'glycoprotein IIb/IIIa inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'glycoprotein IIb/IIIa inhibitors' category:
- eptifibatide
- tirofiban
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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