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Warfarin Therapy: The B.E.S.T. Course

Medically reviewed by Carmen Pope, BPharm. Last updated on March 23, 2023.

Melody L. Berg


Warfarin is a commonly prescribed anticoagulant (blood thinner). It is used to prevent clots caused by an abnormal heart rhythm, after a heart attack or stroke, or following surgery.

Warfarin can save your life. However, like all drugs, it can be harmful if not used correctly. Patients who receive warfarin therapy also receive a lot of information, including information on when to take the drug, what side effects to expect, what to eat, etc.

There is an easy-to-follow principle called “B.E.S.T.” that can help guide you.

  • Be careful: Anticoagulants work by decreasing the clotting ability of the blood. That's good to prevent clots, but it also means you'll bleed more easily if hurt. Be careful when participating in sports, completing household repairs, or other physical activities. If you do get hurt, seek medical attention if significant bleeding occurs. Also, report any unusual bruising to your pharmacist or physician.
  • Eat right: Eating healthy is always important, but even more so when you are taking warfarin. Foods high in Vitamin K, such as green leafy vegetables like spinach, brussels sprouts, broccoli, and mustard greens, can interfere with warfarin. You can still eat these foods, but it's important that you not change how much you eat.
  • Stick to a routine: It's very important that you take warfarin as prescribed. Don't skip doses or change the dose unless your doctor tells you to. Establish a routine by using a pill-reminder box and by taking the drug at the same time every day. Tell your doctor and pharmacist before you start or stop taking another prescription or nonprescription medication, or a supplement.
  • Test regularly: Your doctor will schedule blood tests to monitor your response to warfarin. These tests ensure that the drug is working and help prevent adverse effects. Few people like needles, but these blood tests are an important part of your care. A little discomfort is a small price to pay for your health and safety!

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AHFS® Patient Medication Information is used with permission. ©2024, the American Society of Health-System Pharmacists, Inc. (ASHP). The ASHP Data is a part of the AHFS Drug Information®️; ASHP is not responsible for the accuracy of transpositions from the original context.