Trametinib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with trametinib.
Trametinib Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce as well as delay the absorption of trametinib. In study subjects, administration of a single dose of trametinib with a high-fat, high-calorie meal decreased peak plasma concentration (Cmax) and systemic exposure (AUC) by 70% and 24%, respectively, and delayed Tmax by approximately 4 hours compared to administration in the fasted state.
MANAGEMENT: Trametinib should be taken at least 1 hour before or 2 hours after a meal.
References (1)
- (2013) "Product Information. Mekinist (trametinib)." GlaxoSmithKline
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Trametinib drug interactions
There are 33 drug interactions with trametinib.
Trametinib disease interactions
There are 9 disease interactions with trametinib which include:
- lung toxicity
- cardiomyopathy
- GI perforation
- hemorrhage
- hepatic impairment
- hyperglycemia
- ocular toxicities
- renal impairment
- venous thromboembolism
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More about trametinib
- trametinib consumer information
- Check interactions
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- Reviews (3)
- Side effects
- Dosage information
- During pregnancy
- Drug class: multikinase inhibitors
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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