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Aubagio (teriflunomide) and Alcohol / Food Interactions

There are 3 alcohol/food/lifestyle interactions with Aubagio (teriflunomide) which include:


Caffeine ↔ teriflunomide

Moderate Drug Interaction

Consumer information for this interaction is not currently available.

MONITOR: Coadministration with teriflunomide may decrease the plasma concentrations and therapeutic effects of drugs that are substrates of CYP450 1A2. The proposed mechanism is increased clearance due to teriflunomide-mediated induction of CYP450 1A2. Multiple doses of teriflunomide decreased mean Cmax and AUC of caffeine, a known CYP450 1A2 substrate, by 18% and 55%, respectively.

MANAGEMENT: Caution is advised if teriflunomide is used concomitantly with drugs that are substrates of CYP450 1A2. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever teriflunomide is added to or withdrawn from therapy with these drugs.


  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. "Product Information. Aubagio (teriflunomide)." Genzyme Corporation, Cambridge, MA.

Alcohol (Ethanol) ↔ teriflunomide

Major Drug Interaction

Teriflunomide may cause liver problems, and using it with other medications that can also affect the liver such as ethanol may increase that risk. Because teriflunomide can stay in your blood for a prolonged period after the last dose, interactions with other drugs may occur for some time even after you have stopped taking it. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data


High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

teriflunomide - hypertension

Teriflunomide may increase the blood pressure. Caution should be taken when using this agent in hypertensive patients. It is recommended to check blood pressure before the start of teriflunomide treatment and periodically thereafter and elevated blood pressure should be appropriately managed during treatment with teriflunomide.

Aubagio (teriflunomide) drug Interactions

There are 867 drug interactions with Aubagio (teriflunomide)

Aubagio (teriflunomide) disease Interactions

There are 9 disease interactions with Aubagio (teriflunomide) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.