Krintafel and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Krintafel (tafenoquine).
Tafenoquine Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of tafenoquine. According to the manufacturer, tafenoquine peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 31% and 41%, respectively, when administered as an investigational capsule formulation with a high-calorie, high-fat meal (approximately 1000 calories; 15% protein, 25% carbohydrate, 60% fat) relative to the fasted state.
MANAGEMENT: Tafenoquine should be administered with food.
References (1)
- (2018) "Product Information. Krintafel (tafenoquine)." GlaxoSmithKline
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Krintafel drug interactions
There are 36 drug interactions with Krintafel (tafenoquine).
Krintafel disease interactions
There are 3 disease interactions with Krintafel (tafenoquine) which include:
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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