Bactrim DS and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Bactrim DS (sulfamethoxazole / trimethoprim).
Sulfamethoxazole Alcohol (Ethanol)
Moderate Drug Interaction
MONITOR: Two cases have been reported in which patients on sulfamethoxazole-trimethoprim therapy, after consuming beer, reported flushing, heart palpitations, dyspnea, headache, and nausea (disulfiram - alcohol type reactions). First-generation sulfonylureas have been reported to cause facial flushing when administered with alcohol by inhibiting acetaldehyde dehydrogenase and subsequently causing acetaldehyde accumulation. Since sulfamethoxazole is chemically related to first-generation sulfonylureas, a disulfiram-like reaction with products containing sulfamethoxazole is theoretically possible. However, pharmacokinetic/pharmacodynamic data are lacking and in addition, the two reported cases cannot be clearly attributed to the concomitant use of sulfamethoxazole-trimethoprim and alcohol.
MANAGEMENT: Patients should be alerted to the potential for this interaction and although the risk for this interaction is minimal, caution is recommended while taking sulfamethoxazole-trimethoprim concomitantly with alcohol.
References (2)
- Heelon MW, White M (1998) "Disulfiram-cotrimoxazole reaction." Pharmacotherapy, 18, p. 869-70
- Mergenhagen KA, Wattengel BA, Skelly MK, Clark CM, Russo TA (2020) "Fact versus fiction: a review of the evidence behind alcohol and antibiotic interactions." Antimicrob Agents Chemother, 64, e02167-19
Switch to consumer interaction data
Bactrim DS drug interactions
There are 456 drug interactions with Bactrim DS (sulfamethoxazole / trimethoprim).
Bactrim DS disease interactions
There are 12 disease interactions with Bactrim DS (sulfamethoxazole / trimethoprim) which include:
- colitis
- hematologic toxicity
- hypersensitivity reactions
- liver disease
- porphyria
- renal dysfunction
- folate deficiency
- crystalluria
- hemodialysis
- urinary obstruction
- dialysis
- renal dysfunction
More about Bactrim DS (sulfamethoxazole / trimethoprim)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (391)
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Generic availability
- Support group
- Drug class: sulfonamides
- En español
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Bactrim
Bactrim (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections, urinary ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
SMZ-TMP DS
SMZ-TMP DS (sulfamethoxazole and trimethoprim) is an antibiotic used to treat ear infections ...
Co-trimoxazole
Co-trimoxazole is used for bacterial infection, bacterial skin infection, bronchitis ...
Septra
Septra is an antibiotic containing sulfamethoxazole and trimethoprim used to treat ear infections ...
Septra DS
Septra DS is used for bacterial infection, bacterial skin infection, bronchitis, diverticulitis ...
Polysporin First Aid Antibiotic Ointment
Polysporin First Aid Antibiotic Ointment is used for bacterial skin infection
Triple Antibiotic
Triple Antibiotic is used for bacterial skin infection
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.