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Vosevi (sofosbuvir / velpatasvir / voxilaprevir) and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with Vosevi (sofosbuvir / velpatasvir / voxilaprevir):


voxilaprevir ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Administration with food enhances the oral bioavailability of sofosbuvir, velpatasvir, and voxilaprevir. Relative to fasting conditions, mean sofosbuvir systemic exposure (AUC) increased by 64% to 144%, mean velpatasvir AUC increased by 40% to 166%, and mean voxilaprevir AUC increased by 112% to 435% when the combined sofosbuvir/velpatasvir/voxilaprevir formulation is administered with food.

MANAGEMENT: Sofosbuvir/velpatasvir/voxilaprevir should be administered with food.


  1. "Product Information. Vosevi (sofosbuvir/velpatasvir/voxilaprevir)." Gilead Sciences, Foster City, CA.

Vosevi (sofosbuvir / velpatasvir / voxilaprevir) drug interactions

There are 205 drug interactions with Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Vosevi (sofosbuvir / velpatasvir / voxilaprevir) disease interactions

There is 1 disease interaction with Vosevi (sofosbuvir / velpatasvir / voxilaprevir):

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.