Remdesivir and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with remdesivir.
Alcohol (Ethanol) Remdesivir
Moderate Drug Interaction
MONITOR: Concomitant use of remdesivir with other agents that are known to induce hepatotoxicity may theoretically increase the risk of liver injury. Data from investigational use and clinical studies suggest that remdesivir may be associated with transaminase elevations. Transient treatment-emergent Grade 1 or Grade 2 elevations in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed during multiple-dose Phase 1 studies in healthy volunteers. The mechanism of potential hepatotoxicity is unknown and the contribution of remdesivir is difficult to determine, as transaminase elevations have also been reported as a component of COVID-19, including in patients receiving placebo in clinical trials of remdesivir.
MANAGEMENT: Caution and increased monitoring may be required if remdesivir is given concurrently with other agents associated with liver injury. Hepatic function should be evaluated prior to starting remdesivir and during treatment as clinically appropriate. The manufacturer of remdesivir recommends considering discontinuation of remdesivir if ALT levels increase to > 10 times the upper limit of normal. Additionally, the manufacturer recommends discontinuing remdesivir if ALT elevation is accompanied by signs or symptoms of liver inflammation. The labeling of the other agent(s) involved should also be consulted as they may contain dose adjustment or discontinuation recommendations for those agent(s) in the event of hepatotoxicity.
References
- (2023) "Product Information. Veklury (remdesivir)." Gilead Sciences Canada Inc
- (2024) "Product Information. Veklury (remdesivir)." Gilead Sciences Pty Ltd, 6
- (2024) "Product Information. Veklury (remdesivir)." Gilead Sciences Ltd
- (2024) "Product Information. Veklury (remdesivir)." Gilead Sciences
Remdesivir drug interactions
There are 394 drug interactions with remdesivir.
Remdesivir disease interactions
There are 2 disease interactions with remdesivir which include:
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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