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Remdesivir

Pronunciation: rem DE si vir
Generic name: remdesivir
Brand name: Veklury
Dosage form: intravenous powder for injection (100 mg), intravenous solution (5 mg/mL)
Drug class: Purine nucleosides

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 10, 2024.

What is remdesivir?

Remdesivir is used to treat COVID-19 in adults and children from birth who weigh at least 3 pounds (1.5 kilograms) and are hospitalized or are not hospitalized and have mild-to-moderate COVID-19 and are at high risk for progression to severe COVID-19, including hospitalization or death.

Remdesivir may also be used for purposes not listed in this medication guide.

Remdesivir side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Some side effects may occur during or after the injection. Tell your medical caregivers if you feel dizzy, nauseated, light-headed, itchy, sweaty, have a headache or uneven heart rate, chest tightness, back pain, trouble breathing, or swelling in your face.

Remdesivir may cause serious side effects. Call your doctor at once if you have:

Common side effects of remdesivir may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Warnings

Remdesivir is for use only in certain people with COVID-19. You must remain under the care of a doctor while receiving remdesivir.

Before taking this medicine

You should not be treated with remdesivir if you are allergic to it or any of its ingredients.

Tell your doctor if you have or have ever had:

It is not known if remdesivir will harm an unborn baby if received during the first trimester of pregnancy. Having COVID-19 during pregnancy may cause complications or medical problems in both mother and baby. The benefit of treating COVID-19 may outweigh any risks to the baby. Tell your doctor right away if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of remdesivir on you and the baby.

How is remdesivir given?

Remdesivir is given as an infusion into a vein. A healthcare provider will give you this injection.

Remdesivir must be given slowly, and the infusion can take 30 to 120 minutes to complete.

Remdesivir doses are based on weight. Your dose may change if you gain or lose weight. You will receive remdesivir once a day for 3 to up to 10 days, depending on whether you are hospitalized. Your doctor will determine how long you should receive remdesivir.

You will be watched during and for at least one hour after the injection to make sure you do not have an allergic reaction.

You will need certain blood tests before starting and during treatment with remdesivir.

You must remain under the care of a doctor while you are being treated with remdesivir.

Remdesivir dosing information

Usual Remdesivir Adult Dose for COVID-19:

Loading dose (Day 1): 200 mg IV as a single dose
Maintenance dose (from Day 2): 100 mg IV once a day

Duration of Therapy:
-Hospitalized patients requiring invasive mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO): 10 days total
-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement is shown.
-Nonhospitalized patients: 3 days total

Use: For the treatment of coronavirus disease 2019 (COVID-19) in patients who are:
-Hospitalized, or
-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Usual Remdesivir Pediatric Dose for COVID-19:

Less than 28 days old and at least 1.5 kg:

-Loading dose (Day 1): Remdesivir 2.5 mg/kg IV as a single dose
-Maintenance dose (from Day 2): Remdesivir 1.25 mg/kg IV once a day

At least 28 days old and 1.5 to 3 kg:

-Loading dose (Day 1): Remdesivir 2.5 mg/kg IV as a single dose
-Maintenance dose (from Day 2): Remdesivir 1.25 mg/kg IV once a day

At least 28 days old and 3 kg to less than 40kg:

-Loading dose (Day 1): Remdesivir 5 mg/kg IV as a single dose
-Maintenance dose (from Day 2): Remdesivir 2.5 mg/kg IV once a day

Weight at least 40 kg:

-Loading dose (Day 1): 200 mg IV as a single dose
-Maintenance dose (from Day 2): 100 mg IV once a day

Duration of Therapy:
-Hospitalized patients requiring invasive mechanical ventilation and/or ECMO: 10 days total
-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement shown
-Nonhospitalized patients: 3 days total

Comments:
-The lyophilized powder formulation is the only approved dosage form for pediatric patients weighing 1.5 to less than 40 kg.

Use: For the treatment of COVID-19 in patients who are:
-Hospitalized, or
-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Paxlovid, Actemra, Lagevrio, molnupiravir, remdesivir, tocilizumab

What happens if I miss a dose?

In a medical setting, you are not likely to miss a dose.

What happens if I overdose?

In a medical setting, an overdose would be treated quickly.

What should I avoid while receiving remdesivir?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect remdesivir?

Tell your doctor about all your other medicines, especially if you are taking chloroquine or hydroxychloroquine. Either of these medicines could make remdesivir less effective.

Other drugs may affect remdesivir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Does remdesivir interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.