Ponatinib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with ponatinib.
Ponatinib Food
Moderate Food Interaction
GENERALLY AVOID: Coadministration with grapefruit juice is likely to increase the plasma concentrations of ponatinib, which is primarily metabolized by CYP450 3A4. However, the interaction has not been studied. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
MANAGEMENT: The consumption of grapefruit, grapefruit juice, and supplements that contain grapefruit extract should be avoided during treatment with ponatinib.
References (1)
- (2012) "Product Information. Iclusig (ponatinib)." Ariad Pharmaceuticals Inc
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Ponatinib drug interactions
There are 605 drug interactions with ponatinib.
Ponatinib disease interactions
There are 5 disease interactions with ponatinib which include:
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- Drug class: BCR-ABL tyrosine kinase inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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