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Ponatinib Dosage

Medically reviewed by Drugs.com. Last updated on Apr 3, 2023.

Applies to the following strengths: 30 mg; 45 mg; 15 mg; 10 mg

Usual Adult Dose for Chronic Myelogenous Leukemia

Chronic phase chronic myeloid leukemia (CP-CML):


Accelerated phase chronic myeloid leukemia (AP-CML), blast phase chronic myeloid leukemia (BP-CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL):

Comments:

Uses:

Usual Adult Dose for Acute Lymphoblastic Leukemia

Chronic phase chronic myeloid leukemia (CP-CML):


Accelerated phase chronic myeloid leukemia (AP-CML), blast phase chronic myeloid leukemia (BP-CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL):

Comments:

Uses:

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

ANY LEVEL OF LIVER DYSFUNCTION (CHILD-PUGH A, B, OR C):


IF HEPATOTOXICITY DEVELOPS DURING TREATMENT:
Elevation of liver transaminase greater than 3 times the upper limit of normal (ULN) and if:

Dose Adjustments


DOSAGE MODIFICATION FOR COADMINISTRATION OF STRONG CYP450 3A INHIBITORS/INDUCERS:

RECOMMENDED DOSE REDUCTION FOR ADVERSE REACTIONS:

HEPATOTOXICITY:
Elevation of liver transaminase greater than 3 times the upper limit of normal (ULN) and if:

ELEVATED LIPASE/PANCREATITIS:

MYELOSUPPRESSION:

ARTERIAL OCCLUSIVE EVENTS:
Cardiovascular or Cerebrovascular:

Peripheral vascular and other or venous thromboembolic events:

HEART FAILURE:

OTHER NON-HEMATOLOGIC ADVERSE REACTIONS:

Precautions

US BOXED WARNING:
ARTERIAL OCCLUSION, VENOUS THROMBOEMBOLISM, HEART FAILURE, AND HEPATOTOXICITY:


CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration Advice:


Storage Requirements:

Monitoring:

Patient Advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.