Loxitane IM and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with Loxitane IM (loxapine).
Loxapine Food
Moderate Food Interaction
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References (4)
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
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Loxitane IM drug interactions
There are 423 drug interactions with Loxitane IM (loxapine).
Loxitane IM disease interactions
There are 21 disease interactions with Loxitane IM (loxapine) which include:
- dementia
- CNS depression/coma
- related psychosis
- previous neuroleptic malignant syndrome (NMS)
- seizure disorders
- acute alcohol intoxication
- cardiovascular disease
- CNS depression
- NMS
- seizure
- cardiovascular disease
- glaucoma
- hyperprolactinemia/breast cancer
- intestinal obstruction
- neutropenia
- anticholinergic effects
- dehydration
- hyperprolactinemia
- liver disease
- parkinsonism
- tardive dyskinesia
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More about Loxitane IM (loxapine)
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- During pregnancy
- Drug class: miscellaneous antipsychotic agents
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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