Kisqali Femara Co-Pack (letrozole / ribociclib) and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Kisqali Femara Co-Pack (letrozole / ribociclib) which include:
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Pomegranates and grapefruit may increase the systemic exposure to ribociclib. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in these fruits. Increased exposure to ribociclib may increase the risk of adverse effects such as infections, neutropenia, leukopenia, anemia, thrombocytopenia, anorexia, nausea, vomiting, diarrhea, stomatitis, alopecia, fatigue, headache, and abnormal liver function may be increased.
MANAGEMENT: Patients receiving ribociclib should avoid consumption of pomegranates or pomegranate juice and grapefruit or grapefruit juice during treatment.
- "Product Information. Kisqali (ribociclib)." Novartis Pharmaceuticals, East Hanover, NJ.
High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)
Moderate Potential Hazard, Moderate plausibility
letrozole - cholesterol
In an adjuvant clinical trial hypercholesterolemia was reported in 52.3% of letrozole patients and 28.6% of tamoxifen patients. CTC grade 3-4 hypercholesterolemia was reported in 0.4% of letrozole patients and 0.1% of tamoxifen patients. Also in the adjuvant setting, an increase of >=1.5 X ULN in total cholesterol (generally non-fasting) was observed in patients on monotherapy who had baseline total serum cholesterol within the normal range (i.e., <=1.5 X ULN) in 151/1843 (8.2%) on letrozole vs 57/1840 (3.2%). Caution is recommended when prescribing letrozole to these patients. Consideration should be given to monitoring serum cholesterol.
Kisqali Femara Co-Pack (letrozole / ribociclib) drug interactions
There are 642 drug interactions with Kisqali Femara Co-Pack (letrozole / ribociclib)
Kisqali Femara Co-Pack (letrozole / ribociclib) disease interactions
There are 9 disease interactions with Kisqali Femara Co-Pack (letrozole / ribociclib) which include:
- liver disease
- Ribociclib – arrhythmias
- lung toxicity
- cutaneous toxicity
- hepatic impairment
- renal impairment
More about Kisqali Femara Co-Pack (letrozole / ribociclib)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- Drug class: antineoplastic combinations
Related treatment guides
Drug Interaction Classification
|No interaction information available.|