Rebetron (interferon alfa-2b / ribavirin) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Rebetron (interferon alfa-2b / ribavirin):
ribavirin ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Food enhances the oral absorption and bioavailability of ribavirin. Administration of a single oral dose of ribavirin following a high-fat meal delayed absorption (Tmax was doubled) but increased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by up to 70% compared to administration in the fasting state.
MANAGEMENT: To ensure maximal oral absorption, ribavirin should be administered with or immediately after a meal.
- "Product Information. Copegus (ribavirin)." Roche Laboratories, Nutley, NJ.
- "Product Information. Rebetol (ribavirin)." Schering-Plough Corporation, Kenilworth, NJ.
Rebetron (interferon alfa-2b / ribavirin) drug Interactions
There are 243 drug interactions with Rebetron (interferon alfa-2b / ribavirin)
Rebetron (interferon alfa-2b / ribavirin) disease Interactions
There are 14 disease interactions with Rebetron (interferon alfa-2b / ribavirin) which include:
- Renal Dysfunction
- Autoimmune Diseases
- Hepatic Dysfunction
- Cardiac Disease
- Cns Dysfunction
- Thyroid Dysfunction
- Pulmonary Deterioration
- Renal Dysfunction
- Diabetes Mellitus
- Peripheral Neuropathy
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.