Velcade (bortezomib) and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Velcade (bortezomib) which include:
multivitamins with minerals bortezomib
Moderate Drug Interaction
Talk to your doctor before using bortezomib together with multivitamin with minerals. Supplements that contain ascorbic acid, or vitamin C, may reduce the effectiveness of bortezomib in treating your cancer. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Data from in vitro and animal (mice) studies suggest that green tea may antagonize the cytotoxic effects of bortezomib. Polyphenols in green tea such as (-)-epigallocatechin gallate (EGCG) have been shown to block the proteasome inhibitory action of bortezomib in multiple myeloma and glioblastoma cancer cell lines. The mechanism appears to involve a direct chemical reaction between the boronic acid moiety of bortezomib and the 1,2-benzenediol groups present in certain polyphenols leading to inactivation of bortezomib. However, one group of investigators reported that no antagonism of bortezomib was observed in preclinical in vivo experiments where EGCG plasma concentrations are commensurate with dietary or supplemental intake.
MANAGEMENT: Until more data are available, it may be advisable to avoid or limit consumption of green tea and green tea products during treatment with bortezomib. The interaction has not been demonstrated for other, non-boronic acid proteasome inhibitors.
- Bannerman B, Xu L, Jones M, et al "Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea." Cancer Chemother Pharmacol 68 (2011): 1145-54
- Jia L, Liu FT "Why bortezomib cannot go with 'green'?" Cancer Biol Med 10 (2013): 206-13
- Golden EB, Lam PY, Kardosh A, et.al "Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid–based proteasome inhibitors." Blood 113 (2009): 5927-37
Velcade (bortezomib) drug interactions
There are 380 drug interactions with Velcade (bortezomib)
Velcade (bortezomib) disease interactions
There are 6 disease interactions with Velcade (bortezomib) which include:
More about Velcade (bortezomib)
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- Drug class: proteasome inhibitors
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|