Afatinib and Alcohol/Food Interactions
There is 1 alcohol/food/lifestyle interaction with afatinib.
Afatinib Food
Moderate Food Interaction
ADJUST DOSING INTERVAL: Food may reduce the oral bioavailability of afatinib. According to the product labeling, administration of afatinib with a high-fat meal decreased peak plasma concentration (Cmax) by 50% and systemic exposure (AUC) by 39% compared to administration in the fasted state.
MANAGEMENT: Afatinib should be taken at least 1 hour before or 2 hours after a meal.
References (1)
- (2013) "Product Information. Gilotrif (afatinib)." Boehringer Ingelheim
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Afatinib drug interactions
There are 183 drug interactions with afatinib.
Afatinib disease interactions
There is 1 disease interaction with afatinib which include:
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- Drug class: multikinase inhibitors
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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