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Afatinib Dosage

Medically reviewed on November 13, 2017.

Applies to the following strengths: 30 mg; 40 mg; 20 mg

Usual Adult Dose for Non-Small Cell Lung Cancer

40 mg orally once a day

Duration of therapy: Until disease progression or no longer tolerated by patient.

Comments: Administer at least 1 hour before or 2 hours after a meal

Renal Dose Adjustments

-Mild Renal Dysfunction (CrCl 60 to 89 mL/min): No adjustment recommended.
-Moderate Renal Dysfunction (CrCl 30 to 59 mL/min): Closely monitor patients and adjust dose if not tolerated.
-Severe Renal Dysfunction (CrCl less than 30 mL/min): No data available. Closely monitor patients and adjust dose if not tolerated.

Liver Dose Adjustments

-Mild to Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended
-Severe Liver Dysfunction (Child-Pugh if available): No data available. Closely monitor patients and adjust dose if not tolerated.

Dose Adjustments

Withhold for any drug-related adverse reactions of:
-National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade 3 or higher
-Diarrhea of Grade 2 or higher persisting for 2 or more consecutive days while taking antidiarrheal medication.
-Cutaneous reactions of Grade 2 that are prolonged (lasting more than 7 days) or intolerable.
-Renal dysfunction of Grade 2 or higher

Resume treatment when the adverse reaction fully resolves, returns to baseline, or improves to Grade 1. Reinstitute afatinib at a reduced dose, i.e., 10 mg per day less than the dose at which the adverse reaction occurred.

Permanently discontinue for:

-Life-threatening bullous, blistering, or exfoliative skin lesions
-Confirmed interstitial lung disease (ILD)
-Severe drug-induced hepatic impairment
-Persistent ulcerative keratitis
-Symptomatic left ventricular dysfunction
-Severe or intolerable adverse reaction occurring at a dose of 20 mg per day

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

Administration advice: Do not take a missed dose within 12 hours of the next dose. Take at least 1 hour before or 2 hours after a meal

Storage requirements: Dispense medication in the original container to protect from exposure to high humidity and light.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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