Applies to the following strength(s): 30 mg ; 40 mg ; 20 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Non-Small Cell Lung Cancer
40 mg orally once a day
Duration of therapy: Until disease progression or no longer tolerated by patient.
Comments: Administer at least 1 hour before or 2 hours after a meal
Renal Dose Adjustments
-Mild Renal Dysfunction (CrCl 60 to 89 mL/min): No adjustment recommended.
-Moderate Renal Dysfunction (CrCl 30 to 59 mL/min): Closely monitor patients and adjust dose if not tolerated.
-Severe Renal Dysfunction (CrCl less than 30 mL/min): No data available. Closely monitor patients and adjust dose if not tolerated.
Liver Dose Adjustments
-Mild to Moderate Liver Dysfunction (Child-Pugh A or B): No adjustment recommended
-Severe Liver Dysfunction (Child-Pugh if available): No data available. Closely monitor patients and adjust dose if not tolerated.
Withhold for any drug-related adverse reactions of:
-National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Grade 3 or higher
-Diarrhea of Grade 2 or higher persisting for 2 or more consecutive days while taking antidiarrheal medication.
-Cutaneous reactions of Grade 2 that are prolonged (lasting more than 7 days) or intolerable.
-Renal dysfunction of Grade 2 or higher
Resume treatment when the adverse reaction fully resolves, returns to baseline, or improves to Grade 1. Reinstitute afatinib at a reduced dose, i.e., 10 mg per day less than the dose at which the adverse reaction occurred.
Permanently discontinue for:
-Life-threatening bullous, blistering, or exfoliative skin lesions
-Confirmed interstitial lung disease (ILD)
-Severe drug-induced hepatic impairment
-Persistent ulcerative keratitis
-Symptomatic left ventricular dysfunction
-Severe or intolerable adverse reaction occurring at a dose of 20 mg per day
Consult WARNINGS section for dosing related precautions.
Data not available
Administration advice: Do not take a missed dose within 12 hours of the next dose. Take at least 1 hour before or 2 hours after a meal
Storage requirements: Dispense medication in the original container to protect from exposure to high humidity and light.
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Other brands: Gilotrif