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Darvocet A500 (acetaminophen / propoxyphene) and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with Darvocet A500 (acetaminophen / propoxyphene):


propoxyphene ↔ food

Major Food Interaction

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Alcohol may have additive CNS- and/or respiratory-depressant effects with propoxyphene. Misuse of propoxyphene, either alone or in combination with other CNS depressants, has been a major cause of drug-related deaths, particularly in patients with a history of emotional disturbances, suicidal ideation, or alcohol and drug abuse.

MANAGEMENT: The use of alcohol during propoxyphene therapy should be avoided. Patients should be warned not to exceed the recommended dosage of propoxyphene and to avoid activities requiring mental alertness until they know how these agents affect them.


  1. "Product Information. Darvon (propoxyphene)." Lilly, Eli and Company, Indianapolis, IN.

Darvocet A500 (acetaminophen / propoxyphene) drug interactions

There are 1117 drug interactions with Darvocet A500 (acetaminophen / propoxyphene)

Darvocet A500 (acetaminophen / propoxyphene) disease interactions

There are 19 disease interactions with Darvocet A500 (acetaminophen / propoxyphene) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.