Generic Name: hepatitis B adult vaccine (HEP a TYE tis B a DULT VAX een)
Brand Names: Engerix-B, Recombivax HB Adult, Recombivax HB Dialysis Formulation
Medically reviewed by Sanjai Sinha, MD Last updated on Apr 7, 2019.
What is Engerix-B?
Engerix-B vaccine is used to help prevent hepatitis B in adults.
Hepatitis is a serious disease caused by a virus. Hepatitis causes inflammation of the liver, and may cause vomiting, and jaundice (yellowing of the skin or eyes). Hepatitis can lead to liver cancer, cirrhosis, or death. Hepatitis can also cause no symptoms.
Hepatitis B is a disease of the liver that is spread through blood or bodily fluids, sexual contact or sharing IV drug needles with an infected person, or during childbirth when the mother is infected.
Engerix-B works by exposing you to a small amount of the virus, which causes the body to develop immunity to the disease. Engerix-B will not treat an active infection that has already developed in the body.
Vaccination with hepatitis B adult vaccine is recommended for all adults who are at risk of getting hepatitis B. Risk factors include: having more than one sex partner; being a homosexual male; having sexual contact with infected people; having chronic liver disease; having diabetes and being under age 60; having HIV or AIDS; using intravenous (IV) drugs; being on dialysis or receiving blood transfusions; working in an institution for developmentally disabled patients; working in healthcare or public safety and being exposed to human blood; being in the military or traveling to high-risk areas; and living with a person who has hepatitis B.
Like any vaccine, the Engerix-B may not provide protection from disease in every person.
You should not receive Engerix-B if you are allergic to baker's yeast.
Engerix-B will not protect against hepatitis B if you are already infected with the virus, even if you do not yet show symptoms.
Before taking this medicine
Engerix-B will not protect against infection with hepatitis A, C, and E, or other viruses that affect the liver. It may also not protect against hepatitis B if you are already infected with the virus, even if you do not yet show symptoms.
You should not receive Engerix-B if you have ever had a life-threatening allergic reaction to any vaccine containing hepatitis B, or if you are allergic to baker's yeast.
If you have any of these other conditions, your vaccine may need to be postponed or not given at all:
kidney disease (or if you are on dialysis);
a bleeding or blood clotting disorder such as hemophilia or easy bruising;
an allergy to latex rubber; or
a neurologic disorder or disease affecting the brain (or if this was a reaction to a previous vaccine).
You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving Engerix-B.
It is not known whether Engerix-B will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while receiving the series of Engerix-Bs.
It is not known whether hepatitis B vaccine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How is Engerix-B given?
Engerix-B is given as an injection (shot) into a muscle. You will receive this injection in a doctor's office or other clinic setting.
The Engerix-B is given in a series of shots. The booster shots are sometimes given 1 month and 6 months after the first shot. If you have a high risk of hepatitis B infection, you may be given an additional booster 1 to 2 months after the third shot.
Your individual booster schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by your local health department.
Hepatitis B adult vaccine dosing information
Usual Adult Dose for Hepatitis B Prophylaxis:
Ages 19 and younger: Three doses (10 mcg each), IM, on a 0, 1, and 6 month schedule
Ages 20 and older: Three doses (20 mcg each), IM, on a 0, 1, and 6 month schedule
Start Engerix-B as soon as possible after exposure.
What happens if I miss a dose?
Contact your doctor if you will miss a booster dose or if you get behind schedule. The next dose should be given as soon as possible. There is no need to start over.
Be sure to receive all recommended doses of Engerix-B. You may not be fully protected if you do not receive the full series.
What happens if I overdose?
An overdose of Engerix-B is unlikely to occur.
What should I avoid before or after receiving Engerix-B?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Engerix-B side effects
Get emergency medical help if you have signs of an allergic reaction to Engerix-B: hives; difficult breathing; fast heartbeat; dizziness, weakness; swelling of your face, lips, tongue, or throat.
You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Keep track of any and all side effects you have after receiving Engerix-B. When you receive a booster dose, you will need to tell your doctor if the previous shot caused any side effects.
Becoming infected with hepatitis B is much more dangerous to your health than receiving Engerix-B. However, like any medicine, Engerix-B can cause side effects but the risk of serious side effects is extremely low.
Call your doctor at once if you have:
high fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
changes in behavior;
bruising or bleeding; or
severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Common Engerix-B side effects include:
redness, pain, swelling, or a lump where the shot was given;
diarrhea, loss of appetite;
headache, dizziness, weakness;
feeling tired or irritable; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1-800-822-7967.
What other drugs will affect Engerix-B?
Other drugs may interact with hepatitis B vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Engerix-B only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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- Drug class: viral vaccines
Other brands: Heplisav-B